解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:We have previously reported on paucity of mitochondrial DNA (mtDNA) haplogroups J and K among Finnish endurance athletes. Here we aimed to further explore differences in mtDNA variants between elite endurance and sprint athletes. For this purpose, we determined the rate of functional variants and the mutatio...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6171-6
更新日期:2019-10-29 00:00:00
abstract:BACKGROUND:Aphid (Macrosiphoniella sanbourni) stress drastically influences the yield and quality of chrysanthemum, and grafting has been widely used to improve tolerance to biotic and abiotic stresses. However, the effect of grafting on the resistance of chrysanthemum to aphids remains unclear. Therefore, we used the ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6158-3
更新日期:2019-10-25 00:00:00
abstract:BACKGROUND:The Hafnia genus is an opportunistic pathogen that has been implicated in both nosocomial and community-acquired infections. Although Hafnia is fairly often isolated from clinical material, its taxonomy has remained an unsolved riddle, and the involvement and importance of Hafnia in human disease is also unc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6123-1
更新日期:2019-10-23 00:00:00
abstract:BACKGROUND:Macrobrachium rosenbergii, is one of a major freshwater prawn species cultured in Southeast Asia. White tail disease (WTD), caused by Macrobrachium rosenbergii nodavirus (MrNV), is a serious problem in farm cultivation and is responsible for up to 100% mortality in the post larvae stage. Molecular data on ho...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6102-6
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:While DNA and RNA methods are routine to disrupt the expression of specific genes, complete understanding of developmental processes requires also protein methods, because: oocytes and early embryos accumulate proteins and these are not directly affected by DNA and RNA methods. When proteins in the oocyte en...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6106-2
更新日期:2019-10-21 00:00:00
abstract:BACKGROUND:Chinese wild grapevine (Vitis amurensis) has remarkable cold stress tolerance, exceeding that of the common cultivated grapevine (Vitis vinifera L.). RESULT:Here, we surveyed the expression dynamics of microRNAs (miRNAs) across Chinese wild grapevine (cv. Beibinghong) and cultivated grapevine (cv. Cabernet ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6111-5
更新日期:2019-10-15 00:00:00
abstract:BACKGROUND:Relationships between an organism and its environment can be fundamental in the understanding how populations change over time and species arise. Local ecological conditions can shape variation at multiple levels, among these are the evolutionary history and trajectories of coding genes. This study examines ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6097-z
更新日期:2019-10-12 00:00:00
abstract:BACKGROUND:It is unclear whether improving feed efficiency by selection for low residual feed intake (RFI) compromises pigs' immunocompetence. Here, we aimed at investigating whether pig lines divergently selected for RFI had different inflammatory responses to lipopolysaccharide (LPS) exposure, regarding to clinical p...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6127-x
更新日期:2019-10-11 00:00:00
abstract:BACKGROUND:Gymnosporangium spp. are fungal plant pathogens causing rust disease and most of them are known to infect two different host plants (heteroecious) with four spore stages (demicyclic). In the present study, we sequenced the transcriptome of G. japonicum teliospores on its host plant Juniperus chinensis and we...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6099-x
更新日期:2019-10-09 00:00:00
abstract:BACKGROUND:Our previous study had proved that nigericin could reduce colorectal cancer cell proliferation in dose- and time-dependent manners by targeting Wnt/β-catenin signaling. To better elucidate its potential anti-cancer mechanism, two pancreatic cancer (PC) cell lines were exposed to increasing concentrations of ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6032-3
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND:Accurate de novo genome assembly has become reality with the advancements in sequencing technology. With the ever-increasing number of de novo genome assembly tools, assessing the quality of assemblies has become of great importance in genome research. Although many quality metrics have been proposed and sof...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6070-x
更新日期:2019-09-11 00:00:00
abstract::Following the publication of this article [1], the authors reported that the original shading in columns 3 and 4 of Table 3, which indicated the presence or absence of viruses in each library, had been removed during typesetting. ...
journal_title:BMC genomics
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12864-019-6067-5
更新日期:2019-09-05 00:00:00
abstract:BACKGROUND:Archived formalin fixed paraffin embedded (FFPE) samples are valuable clinical resources to examine clinically relevant morphology features and also to study genetic changes. However, DNA quality and quantity of FFPE samples are often sub-optimal, and resulting NGS-based genetics variant detections are prone...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6056-8
更新日期:2019-09-02 00:00:00
abstract:BACKGROUND:Brain-derived neurotrophic factor (BDNF) is a major signaling molecule that the brain uses to control a vast network of intracellular cascades fundamental to properties of learning and memory, and cognition. While much is known about BDNF signaling in the healthy nervous system where it controls the mitogen ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6033-2
更新日期:2019-08-28 00:00:00
abstract:BACKGROUND:Single cell transcriptome sequencing has become an increasingly valuable technology for dissecting complex biology at a resolution impossible with bulk sequencing. However, the gap between the technical expertise required to effectively work with the resultant high dimensional data and the biological experti...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6053-y
更新日期:2019-08-27 00:00:00
abstract:BACKGROUND:The Yesso scallop, Patinopecten (Mizuhopecten) yessoensis, is a commercially important bivalve in the coastal countries of Northeast Asia. It has complex modes of sex differentiation, but knowledge of the mechanisms underlying this sex determination and differentiation is limited. RESULTS:In this study, the...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6021-6
更新日期:2019-08-23 00:00:00
abstract:BACKGROUND:Petal nectar spurs, which facilitate pollination through animal attraction and pollen placement, represent a key innovation promoting diversification in the genus Aquilegia (Ranunculaceae). Identifying the genetic components that contribute to the development of these three-dimensional structures will inform...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6002-9
更新日期:2019-08-22 00:00:00
abstract:BACKGROUND:Wheat is the most important staple crop in Afghanistan and accounts for the main part of cereal production. However, wheat production has been unstable during the last decades and the country depends on seed imports. Wheat research in Afghanistan has emphasized releases of new, high-yielding and disease resi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6015-4
更新日期:2019-08-19 00:00:00
abstract:BACKGROUND:Genome-scale metabolic models (GSMM) integrating transcriptomics have been widely used to study cancer metabolism. This integration is achieved through logical rules that describe the association between genes, proteins, and reactions (GPRs). However, current gene-to-reaction formulation lacks the stoichiome...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5979-4
更新日期:2019-08-15 00:00:00
abstract:BACKGROUND:Ensifer alkalisoli YIC4027, a recently characterized nitrogen-fixing bacterium of the genus Ensifer, has been isolated from root nodules of the host plant Sesbania cannabina. This plant is widely used as green manure and for soil remediation. E. alkalisoli YIC4027 can grow in saline-alkaline soils and is a n...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6004-7
更新日期:2019-08-12 00:00:00
abstract:BACKGROUND:The Pacific oyster Crassostrea gigas is an important fishery resource that is sensitive to temperature fluctuations. Thus, it has evolved a protection mechanism against heat stress by increasing the expression of the gene coding for heat shock protein (HSP) 70 under elevated temperatures. In other animals, h...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6003-8
更新日期:2019-08-08 00:00:00
abstract:BACKGROUND:The effective use of mutant populations for reverse genetic screens relies on the population-wide characterization of the induced mutations. Genome- and population-wide characterization of the mutations found in fast neutron populations has been hindered, however, by the wide range of mutations generated and...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5998-1
更新日期:2019-08-06 00:00:00
abstract:BACKGROUND:Free asparagine is the precursor for acrylamide formation during cooking and processing of grains, tubers, beans and other crop products. In wheat grain, free asparagine, free glutamine and total free amino acids accumulate to high levels in response to sulphur deficiency. In this study, RNA-seq data were ac...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5991-8
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Quercetin is a polyphenol of great interest given its antioxidant activity and involvement in the immune response. Although quercetin has been well studied at the molecular level as a gene regulator and an activator of specific cellular pathways, not much attention has been given to its mechanism of action a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5966-9
更新日期:2019-07-23 00:00:00
abstract:BACKGROUND:As an important nosocomial pathogen, Enterococcus faecium has received increasing attention in recent years. However, a large number of studies have focused on the hospital-associated isolates and ignored isolates originated from the natural environments. RESULTS:In this study, comparative genomic analysis ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5975-8
更新日期:2019-07-22 00:00:00
abstract:BACKGROUND:A thorough verification of the ability of genomic selection (GS) to predict estimated breeding values for pea (Pisum sativum L.) grain yield is pending. Prediction for different environments (inter-environment prediction) has key importance when breeding for target environments featuring high genotype × envi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5920-x
更新日期:2019-07-22 00:00:00
abstract:BACKGROUND:Short-read resequencing of genomes produces abundant information of the genetic variation of individuals. Due to their numerous nature, these variants are rarely exhaustively validated. Furthermore, low levels of undetected variant miscalling will have a systematic and disproportionate impact on the interpre...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5863-2
更新日期:2019-07-16 00:00:00
abstract:BACKGROUND:Membrane proteins constitute up to 30% of the human proteome. These proteins have special properties because the transmembrane segments are embedded into lipid bilayer while extramembranous parts are in different environments. Membrane proteins have several functions and are involved in numerous diseases. A ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5865-0
更新日期:2019-07-16 00:00:00
abstract:BACKGROUND:Tree peony (Paeonia suffruticosa Andrews) is a globally famous ornamental flower, with large and colorful flowers and abundant flower types. However, a relatively short and uniform flowering period hinders the applications and production of ornamental tree peony. Unfortunately, the molecular mechanism of reg...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5857-0
更新日期:2019-07-11 00:00:00
abstract:BACKGROUND:Reads assignment to taxonomic units is a key step in microbiome analysis pipelines. To date, accurate taxonomy annotation of 16S reads, particularly at species rank, is still challenging due to the short size of read sequences and differently curated classification databases. The close phylogenetic relations...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5914-8
更新日期:2019-07-08 00:00:00
abstract::DpbCasX, also called Cas12e, is an RNA-guided DNA endonuclease isolated from Deltaproteobacteria. In this paper I characterized the CasX-compatible genome editing sites in the reference genomes of yeast (Saccharomyces cerevisiae), flatworms (Caenorhabditis elegans), flies (Drosophila melanogaster), zebrafish (Danio re...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5924-6
更新日期:2019-06-27 00:00:00
abstract:BACKGROUND:Phlebotomine sand flies (Diptera, Nematocera) are important vectors of several pathogens, including Leishmania parasites, causing serious diseases of humans and dogs. Despite their importance as disease vectors, most aspects of sand fly biology remain unknown including the molecular basis of their reproducti...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5898-4
更新日期:2019-06-25 00:00:00
abstract:BACKGROUND:Banana wilt disease, caused by Fusarium oxysporum f. sp. cubense Tropical Race 4 (Foc TR4), is one of the most devastating diseases in banana (Musa spp.). Foc is a soil borne pathogen that causes rot of the roots or wilt of leaves by colonizing the xylem vessels. The dual RNA sequencing is used to simultaneo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5902-z
更新日期:2019-06-24 00:00:00
abstract:BACKGROUND:Dermal papilla cells (DPCs), the "signaling center" of hair follicle (HF), delicately master continual growth of hair in mammals including cashmere, the fine fiber annually produced by secondary HF embedded in cashmere goat skins. Such unparalleled capacity bases on their exquisite character in instructing t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5861-4
更新日期:2019-06-20 00:00:00
abstract:BACKGROUND:The introduction of genome-wide shRNA and CRISPR libraries has facilitated cell-based screens to identify loss-of-function mutations associated with a phenotype of interest. Approaches to perform analogous gain-of-function screens are less common, although some reports have utilized arrayed viral expression ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5888-6
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:Single-cell gene expression measurements offer opportunities in deriving mechanistic understanding of complex diseases, including cancer. However, due to the complex regulatory machinery of the cell, gene regulatory network (GRN) model inference based on such data still manifests significant uncertainty. RE...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5720-3
更新日期:2019-06-13 00:00:00
abstract:BACKGROUND:Juncus effusus L. (family: Juncaceae; order: Poales) is a helophytic rush growing in temperate damp or wet terrestrial habitats and is of almost cosmopolitan distribution. The species has been studied intensively with respect to its interaction with co-occurring plants as well as microbes being involved in m...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5886-8
更新日期:2019-06-13 00:00:00
abstract:BACKGROUND:Reliable indicators for the onset of flowering are not available for most perennial monocarpic species, representing a drawback for crops such as bamboo, agave and banana. The ability to predict and control the transition to the reproductive stage in A. tequilana would represent an advantage for field manage...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5808-9
更新日期:2019-06-10 00:00:00
abstract:BACKGROUND:The WRKY gene family is one of the most important families in higher plants. As transcription factors, they actively respond to biotic and abiotic stress and are also involved in plant development. Chinese jujube (Ziziphus jujuba Mill.) is the largest type of dried fruit tree in China in terms of production,...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5789-8
更新日期:2019-06-07 00:00:00
abstract:BACKGROUND:Genetic diversity within a species reflects population evolution, ecology, and ability to adapt. Genome-wide population surveys of both natural and introduced populations provide insights into genetic diversity, the evolutionary processes and the genetic basis underlying local adaptation. Grass carp is the m...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5872-1
更新日期:2019-06-07 00:00:00